Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000304

Drug Information
SynonymsSK 5265; BW50197; NSC 7364; METOPRINE, METHODICHLOROPHEN; Neuro_000005; NSC7364; C2M; TCMDC-123931; WLN: T6N CNJ BZ DZ ER CG DG& F1; 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; BW-197U; BW 197 U; CPD-10891; Pyrimidine, 2,4-diamino-5-(3,4-dichlorophenyl)-6-methyl-; Metoprine [USAN]; 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE; BW 197U; BW 50,197; AC1L2NGD; DDMP; DB04655; METOPRINE; NCIMech_000234; BW 50-197; AI3-26402; LS-135022; AC1Q2OZ6; BRN 0223622; 197U50; NSC 19494; 7761-45-7; BW 50197; 2aov; NCI60_041610; 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-; CID24466; Metoprine (USAN); BW 1970; CHEMBL264373; 5-(3,4-Dichlorphenyl)-6-methyl-2,4-pyrimidindiamin; NSC19494; D00309; Methodichlorophen; U 197; C11H10Cl2N4; NSC-19494; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine; SMR001565478; CHEBI:166251; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; MLS002701892; U-197
IndicationAdvanced cancer
[ICD9: 140-229   ICD10: C00-C96]

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Canonical SMILESCC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl    
CAS NumberCAS 7761-45-7
PubChem Compound IDCID 24466.
PubChem Substance IDSID 73253.
TargetDihydrofolate reductaseInhibitor[1]
Ref 1Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. Epub 2006 Apr 13. To Reference


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