Therapeutic Targets Database
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TTD Drug ID: DCL000312

Drug Information
NameKW-6002
Synonyms155270-99-8; LS-126708; Istradefylline [USAN:INN]; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione; UNII-2GZ0LIK7T4; CHEMBL431770; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; Istradefylline (JAN/USAN/INN); (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione; 1H-Purine-2,6-dione, 8-((1E)-2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-; AC1NSJVH; 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; CHEBI:222252; KW-6002; L001483; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-7-methyl-, (E)-; D04641; C111599; Istradefylline; CID5311037; KW 6002
CompanyKyowa Hakko Pharmaceuticals
IndicationParkinson's DiseasePhase III    
Structure

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InChI1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)1
1-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChIKeyIQVRBWUUXZMOPW-PKNBQFBNSA-N
Canonical SMILESCCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C    
Isomeric SMILESCCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
CAS NumberCAS 155270-99-8
PubChem Compound IDCID 5311037.
PubChem Substance IDSID 775901.
ClinicalTrials.govNCT00955526;
TargetAdenosine A2a receptorAntagonist[1][2][3][4]
Ref 1The treatment of Parkinson's disease--adenosine A2A receptor antagonists. Nippon Rinsho. 2002 Jan;60(1):112-6. To Reference
Ref 2Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4. To Reference
Ref 3Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol. 2001 Sep;134(1):68-77. To Reference
Ref 4Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5. To Reference



 

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