Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000315

Drug Information
Synonyms1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea; Atreleuton (USAN/INN); 154355-76-7; A-85761; AC1MJ6LB; CHEBI:193440; ABT-761; UNII-U301T88E1M; CID3086671; Atreleuton; ABT 761; D03010; CHEMBL59356; Atreleuton [USAN]
CompanyAbbott Laboratories
[ICD9: 493   ICD10: J45]
Discontinued in Phase III    

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Canonical SMILESCC(C#CC1=CC=C(S1)CC2=CC=C(C=C2)F)N(C(=O)N)O    
Isomeric SMILESC[C@H](C#CC1=CC=C(S1)CC2=CC=C(C=C2)F)N(C(=O)N)O
PubChem Compound IDCID 3086671.
PubChem Substance IDSID 3889586.
TargetArachidonate 5-lipoxygenaseInhibitor[1][2]
Ref 1The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage. Neurosurgery. 2001 Nov;49(5):1205-12; discussion 1212-3. To Reference
Ref 2N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase. Bioorg Med Chem Lett. 1999 Apr 5;9(7):979-84. To Reference


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