Therapeutic Targets Database
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TTD Drug ID: DCL000334

Drug Information
NameGarenoxacin
SynonymsUNII-V72H9867WB; 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid; 223652-82-2 (MESYLATE SALT); T 3811; T-3811; 194804-75-6; CHEMBL215303; AC1L3XUP; BMS-284756 (*Mesylate salt*); Garenoxacin; T-3811MEa; BMS 284756 (*Mesylate salt*); CID124093; NCGC00181770-01; 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 223652-82-2
CompanyToyama Chemical.
IndicationEndocarditis
[ICD9: 421   ICD10: I33]
Discontinued    [1]
Structure

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InChI1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(1
6)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,1
4,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
InChIKeyNJDRXTDGYFKORP-LLVKDONJSA-N
Canonical SMILESCC1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F    
Isomeric SMILESC[C@@H]1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
CAS NumberCAS 91421-42-0
PubChem Compound IDCID 124093.
PubChem Substance IDSID 629682.
SuperDrug ATC IDJ01MA19
TargetDNA topoisomerase IIInhibitor[2]
Ref 1Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. To Reference
Ref 2The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues. J Antimicrob Chemother. 2001 Aug;48(2):195-201. To Reference



 

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