Therapeutic Targets Database
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TTD Drug ID: DCL000336

Drug Information
NameAR-C69931 MX
SynonymsD03361; 163706-36-3; CID5310955; AC1NSJQ8; CHEBI:726138; Cangrelor tetrasodium (USAN); CID10260031; AR-C69931; ARC-69931MX; CHEMBL1097279; Cangrelor tetrasodium; [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate; AR-C69931MX
CompanyAstrazeneca
IndicationAtherosclerosis; Percutaneous Coronary Intervention; Acute Coronary Syndrome; Cardiovascular diseases
[ICD9: 390-459, 411.1, 414.0, 440   ICD10: I00-I99, I20.0, I25.1, I70]
Phase III    
Structure

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InChI1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4
-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-
41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,
(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10
-,11-,14-;;;;/m1..../s1
InChIKeyCOWWROCHWNGJHQ-OPKBHZIBSA-J
Canonical SMILESCSCCNC1=NC(=NC2=C1N=CN2C3C(C(C(O3)COP(=O)([O-])OP(=O)(C(P(=O)([O-])[O-])
(Cl)Cl)[O-])O)O)SCCC(F)(F)F.[Na+].[Na+].[Na+].[Na+]    
Isomeric SMILESCSCCNC1=NC(=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)
(C(P(=O)([O-])[O-])(Cl)Cl)[O-])O)O)SCCC(F)(F)F.[Na+].[Na+].[Na+].[Na+]
CAS NumberCAS 163706-36-3
PubChem Compound IDCID 10260031.
PubChem Substance IDSID 15263392.
ClinicalTrials.govNCT01156571;
TargetP2Y purinoceptor 12Antagonist[1][2][3]
Ref 1DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 2008 Dec;19(8):605-13. To Reference
Ref 2Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor. Thromb Haemost. 2008 Aug;100(2):261-70. To Reference
Ref 3In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):518-23. Epub 2003 Jan 23. To Reference



 

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