Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000342

Drug Information
NameSU-6668
CompanyPfizer / Sugen
IndicationAdvanced solid tumours
[ICD9: 140-199   ICD10: C00-C75, C7A, C7B]
Discontinued    
Structure

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InChI1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6
-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-
9-
InChIKeyNHFDRBXTEDBWCZ-ZROIWOOFSA-N
Canonical SMILESCC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O    
Isomeric SMILESCC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O
Therapeutic ClassAntineoplastic Agents
PubChem Compound IDCID 5329099.
ClinicalTrials.govNCT00024206;
TargetAurora AInhibitor[1][2]
Aurora AMultitarget[1][2]
Aurora BInhibitor[1][2]
Aurora BMultitarget[1][2]
Basic fibroblast growth factor receptor 1 Inhibitor[1][2]
Basic fibroblast growth factor receptor 1 Multitarget[1][2]
Platelet-derived growth factor receptorInhibitor[1][2]
Platelet-derived growth factor receptorMultitarget[1][2]
Vascular endothelial growth factor receptor 2Inhibitor[1][2]
Vascular endothelial growth factor receptor 2Multitarget[1][2]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 2Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies. Clin Cancer Res. 2005 Sep 1;11(17):6240-6. To Reference



 

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