Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000344

Drug Information
NameTykerb
SynonymsCID11557040; CHEMBL1201179; Lapatinib ditosylate (USAN); GW-572016F; GW-572016; Lapatinib tosilate hydrate (JAN); Lapatinib tosilate hydrate; Lapatinib Ditosylate; LAPATINIB DITOSYLATE MONOHYDRATE; Tykerb (TN); Tykerb; Tyverb; D04024; GW-2016; 388082-78-8
CompanyGSK
IndicationBladder, head & neck, NSCLC, brain cancer
[ICD9: 140-229, 162, 188, 191   ICD10: C00-C96, C33, C34, C67, C71]
Phase II completed    
Refractory metastatic breast cancer, RCC
[ICD9: 140-229, 174, 175   ICD10: C00-C96, C50]
Phase III    
Structure

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InChI1S/C29H26ClFN4O4S.2C7H8O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27
(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22
)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10;/h2-10,13
-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10);1
H2
InChIKeyXNRVGTHNYCNCFF-UHFFFAOYSA-N
Canonical SMILESCC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C
(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 388082-78-8
Formula C29H26ClFN4O4S
PubChem Compound IDCID 11557040.
PubChem Substance IDSID 12015501.
ChEBI49603;
SuperDrug ATC IDL01XE07
L01XE07
ClinicalTrials.govNCT00073008;
NCT00558103;
TargetEpidermal growth factor receptorInhibitor[1]
Epidermal growth factor receptorMultitarget[1]
Erbb2Inhibitor[1]
Erbb2Multitarget[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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