Therapeutic Targets Database
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TTD Drug ID: DCL000350

Drug Information
NameVandetanib
SynonymsDB08764; UNII-YO460OQ37K; 338992-00-0; CHEMBL24828; AC1MIWRU; Zactima, ZD6474; ||Zactima; CH 331; ZD 6474|; Vandetanib; Quinazolin-4-amine, N-(4-bromo-2-fluorophenyl)-6-mthoxy-7-[(1-methyl-4-piperidinyl)methoxy]-; C452423; Kinome_3316; LS-184394; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; 4-Quninazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-; EN002713; NCGC00167513-01; CID3081361; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; NSC744325; ZD 6474; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; Zactima; EC-000.2359; AZD-6474; 443913-73-3; Vandetanib, Zactima, ZD6474; MolPort-005-942-399; S1046_Selleck; ZD-6474; F9995-0087; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib [INN]; AC-5251; CH-331; CHEBI:49960; 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-; I14-1942; Vandetanib (JAN/INN); D06407; 2ivu; ZD6474
CompanyAstraZeneca
IndicationBreast, thyroid tumours, multiple myeloma, brain, head & neck cancer
[ICD9: 140-149, 140-199, 140-229, 203.0, 210-229   ICD10: C00-C75, C00-C96, C07-C14, C32, C33, C7A, C7B, C90.0, D10-D36, D3A]
Phase II    
Solid tumours, NSCLC
[ICD9: 140-199, 162, 210-229   ICD10: C00-C75, C33, C34, C7A, C7B, D10-D36, D3A]
Phase III    
Structure

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InChI1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)2
9-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-
8,12H2,1-2H3,(H,25,26,27)
InChIKeyUHTHHESEBZOYNR-UHFFFAOYSA-N
Canonical SMILESCN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 443913-73-3
FormulaC22H24BrFN4O2
PubChem Compound IDCID 3081361.
PubChem Substance IDSID 3882431.
ChEBI49960;
SuperDrug ATC IDL01XE12
L01XE12
ClinicalTrials.govNCT00404924;
NCT00923247;
TargetEpidermal growth factor receptorInhibitor[1][2]
Epidermal growth factor receptorMultitarget[1][2]
Proto-oncogene tyrosine-protein kinase receptor retInhibitor[1][2]
Proto-oncogene tyrosine-protein kinase receptor retMultitarget[1][2]
Vascular endothelial growth factor receptor 2Inhibitor[1][2]
Vascular endothelial growth factor receptor 2Multitarget[1][2]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 2AstraZeneca. Product Development Pipeline. January 29 2009. To Reference



 

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