Therapeutic Targets Database
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TTD Drug ID: DCL000358

Drug Information
NameBMS-582664
SynonymsCHEMBL270995; Brivanib alaninate (INN/USAN); BMS-582664, Brivanib alaninate; CID 11154925; BMS-582664; 649735-63-7; S1138_Selleck; D08878; L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester; UNII-U2Y5OFN795; BMS582664; BMS 582664; Brivanib alaninate; CID11154925
CompanyBristol Myers Squibb
IndicationHepato Cellular Carcinoma (HCC)
[ICD9: 155   ICD10: C22.0]
Phase III    
Structure

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InChI1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)
18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,2
7H,9,24H2,1-4H3/t12-,14+/m1/s1
InChIKeyLTEJRLHKIYCEOX-OCCSQVGLSA-N
Canonical SMILESCC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)OC(=O)C(C)N)C    
Isomeric SMILESCC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)OC(=O)[C@H](C)N)C
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 649735-63-7
FormulaC22H24FN5O4
PubChem Compound IDCID 11154925.
PubChem Substance IDSID 16233765.
ClinicalTrials.govNCT00858871;
TargetFibroblast growth factor receptor 3Inhibitor[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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