Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000361

Drug Information
NameAEE-788
SynonymsCID10297043; CHEMBL587723; AEE-788, NVP-AEE 788, AEE788; GNF-Pf-5343; CHEBI:40629; 497839-62-0; 1H-Pyrrolo(2,3-d)pyrimidin-4-amine, 6-(4-((4-ethyl-1-piperazinyl)methyl)phenyl)-N-((1R)-1-phenylethyl)-; CID 11578515; CID11578515; S1486_Selleck; AEE788; AEE; AEE 788
CompanyNovartis AG
IndicationSolid tumours
[ICD9: 140-199   ICD10: C00-C75, C7A, C7B]
Discontinued in Phase II    
Structure

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InChI1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-1
7-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-
20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)
InChIKeyOONFNUWBHFSNBT-UHFFFAOYSA-N
Canonical SMILESCCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5    
Therapeutic ClassAntineoplastic Agents
FormulaC27H32N6
PubChem Compound IDCID 11578515.
PubChem Substance IDSID 10549896.
ClinicalTrials.govNCT00107237;
TargetFibroblast growth factor receptor 2Inhibitor[1]
Fibroblast growth factor receptor 2Multitarget[1]
Fibroblast growth factor receptor 3Inhibitor[1]
Fibroblast growth factor receptor 3Multitarget[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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