Therapeutic Targets Database
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TTD Drug ID: DCL000363

Drug Information
NamePD-0325901
SynonymsZINC03938683; S06-0029; 391210-10-9; N-[((R)-2,3-dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; PD-325901; N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide; PD0325901; CID9826528; PD-0325901; PD 0325901; CHEMBL507361; N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; PD325901; 870474-62-7; DB07101; S1036_Selleck; C506614; nchembio.282-comp3; 4BM; PD 325901
CompanyPfizer
IndicationNSCLC, melanoma, breast, colon cancer
[ICD9: 140-229, 153, 154, 162, 172   ICD10: C00-C96, C18-C21, C33, C34, C43]
Terminated in Phase II    
Solid tumours
[ICD9: 140-199   ICD10: C00-C75, C7A, C7B]
Terminated in Phase I    
Structure

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InChI1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)1
9)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/
m1/s1
InChIKeySUDAHWBOROXANE-SECBINFHSA-N
Canonical SMILESC1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O    
Isomeric SMILESC1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 870474-62-7
FormulaC16H14F3IN2O4
PubChem Compound IDCID 9826528.
PubChem Substance IDSID 14785709.
ClinicalTrials.govNCT00147550;
NCT00174369;
TargetMEKInhibitor[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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