Therapeutic Targets Database
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TTD Drug ID: DCL000365

Drug Information
NamePD-332991
SynonymsEC-000.2350; 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE; PD-332991; CHEMBL189963; S1116_Selleck; CID5330286; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-; LQQ; 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one; 2euf; Kinome_3823; 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one; PD0332991; 571190-30-2; PD 332991, PD 0332991, PD0332991; AC1NS8RV; Kinome_3824; PD-0332991; PD 0332991
CompanyOnyx Pharmaceuticals/Pfizer
IndicationVarious cancers
[ICD9: 140-229   ICD10: C00-C96]
Phase II    
Structure

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InChI1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-
10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14
,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChIKeyAHJRHEGDXFFMBM-UHFFFAOYSA-N
Canonical SMILESCC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 571190-30-2
FormulaC24H29N7O2
PubChem Compound IDCID 5330286.
PubChem Substance IDSID 8035907.
TargetCell division protein kinase 4Inhibitor[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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