Therapeutic Targets Database
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TTD Drug ID: DCL000366

Drug Information
NameRo 31-7453
SynonymsAC1NS2UU; CID5327686; Bisindolylmaleimide deriv. 44; Ro-31-7453; 3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione; MKC-1; CHEMBL52885
CompanyHoffmann La Roche
IndicationOvarian Cancer; Endometrial Cancer
[ICD9: 140-229, 182.0, 183   ICD10: C00-C96, C54.1, C56]
Phase II    
Structure

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InChI1S/C22H16N4O4/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(1
9)27)16-11-25(2)18-9-12(26(29)30)7-8-14(16)18/h3-11H,1-2H3,(H,23,
27,28)
InChIKeyOVSKGTONMLKNPZ-UHFFFAOYSA-N
Canonical SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=C4C=CC(=C5)[N+](=O)[O-])C    
Therapeutic ClassAntineoplastic Agents
CAS NumberCAS 443912-18-3
PubChem Compound IDCID 5327686.
PubChem Substance IDSID 8032392.
ClinicalTrials.govNCT00607607;
TargetCell division protein kinase 1Inhibitor[1]
Cell division protein kinase 1Multitarget[1]
Cell division protein kinase 2Inhibitor[1]
Cell division protein kinase 2Multitarget[1]
Cell division protein kinase 4Inhibitor[1]
Cell division protein kinase 4Multitarget[1]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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