Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000421

Drug Information
NameAlogliptin
Synonyms2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; MolPort-005-933-065; CHEMBL376359; 850649-61-5; CID11450633; UNII-JHC049LO86; Alogliptin
CompanyTakeda
IndicationDiabetes mellitus
[ICD9: 250   ICD10: E08-E13]
Phase III    
Structure

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InChI1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)1
1-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-
/m1/s1
InChIKeyZSBOMTDTBDDKMP-OAHLLOKOSA-N
Canonical SMILESCN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N    
Isomeric SMILESCN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N
CAS NumberCAS 850649-61-5
PubChem Compound IDCID 11450633.
PubChem Substance IDSID 16549582.
SuperDrug ATC IDA10BH04
ClinicalTrials.govNCT00957268;
TargetDipeptidyl peptidase 4 Inhibitor[1][2][3]
Ref 1Takeda. Product Development Pipeline. July 31 2009. To Reference
Ref 2Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice. Br J Pharmacol. 2009 Jun;157(3):415-26. Epub 2009 Apr 3. To Reference
Ref 3Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. To Reference



 

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