Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000578

Drug Information
NameMotesanib
Synonyms453562-69-1; UNII-U1JK633AYI; ZINC18710082; CID11667893; AMG706; AKOS005146333; N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide; N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-3-pyridinecarboxamide; D06678; Motesanib; CHEMBL572881; AMG-706; AMG 706; CHEBI:51098
CompanyAmgen
IndicationBreast cancer
[ICD9: 174, 175   ICD10: C50]
Phase II    
Non-small cell lung cancer
[ICD9: 162   ICD10: C33, C34]
Phase III    
Structure

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InChI1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-
9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24
,25)(H,27,28)
InChIKeyRAHBGWKEPAQNFF-UHFFFAOYSA-N
Canonical SMILESCC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C    
CAS NumberCAS 453562-69-1
PubChem Compound IDCID 11667893.
PubChem Substance IDSID 16771727.
ChEBI51098;
ClinicalTrials.govNCT00356681;
NCT00460317;
TargetC-kitInhibitor[1][2][3]
C-kitMultitarget[1][2][3]
Platelet-derived growth factor receptorInhibitor[1][2][3]
Platelet-derived growth factor receptorMultitarget[1][2][3]
VEGFR2Inhibitor[1][2][3]
VEGFR2Multitarget[1][2][3]
Ref 1Amgen. Product Development Pipeline. February 6 2009. To Reference
Ref 2Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol. 2009 Aug 10;27(23):3794-801. Epub 2009 Jun 29. To Reference
Ref 3Amgen. Report of Amgen. 2009. To Reference



 

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