Therapeutic Targets Database
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TTD Drug ID: DCL000583

Drug Information
NameOlaparib
Synonyms4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 937799-91-2; AZD2281; KU-0059436; AKOS005145764; Olaparib, KU-0059436, AZD2281, KU0059436, AZD2281; S1060_Selleck; Olaparib; AZD-2281; AZD 2281; EC-000.2324; CHEMBL521686; EN002690; KU-59436; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one; 763113-22-0; FT-0083489; Acylpiperazine analogue, 47
CompanyAstraZeneca
IndicationBreast/ovarian cancer
[ICD9: 174, 175, 183   ICD10: C50, C56]
Phase II    
Structure

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InChI1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-2
1)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16
H,6-7,9-12,14H2,(H,27,30)
InChIKeyFDLYAMZZIXQODN-UHFFFAOYSA-N
Canonical SMILESC1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F    
CAS NumberCAS 763113-22-0
PubChem Compound IDCID 23725625.
PubChem Substance IDSID 47209066.
ClinicalTrials.govNCT00647062;
TargetPoly [ADP-ribose] polymerase 1Inhibitor[1]
Ref 1AstraZeneca. Product Development Pipeline. January 29 2009. To Reference



 

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