Therapeutic Targets Database
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TTD Drug ID: DCL000646

Drug Information
NameSunitinib malate
SynonymsSU010398; N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; (2S)-2-hydroxybutanedioic acid; PNU-290940AD; SU011248; SU-010398; PHA-290940AD; AKOS005145765; FT-0083555; Sunitinib malate [USAN]; Sutent, SU-11248; D06402; SU-011248 L-malate salt; Sunitinib malate; N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate; ST51053712; Sutent (TN); AC1O5CMQ; CHEMBL1567; 341031-54-7; LS-186078; 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1); CHEBI:550864; MolPort-003-986-763; 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1); SU011248 L-malate salt; TL8002546; Sunitinib malate (JAN/USAN); UNII-LVX8N1UT73; CID6456015; Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1); SU-11248 L-malate salt; SU 011248; S1042_Selleck
Trade NameSutent
CompanyPfizer
IndicationMetastatic Renal Cell Carcinoma; Gastrointestinal Stromal Tumors
[ICD9: 140-199, 150-159, 189, 210-229   ICD10: C00-C75, C15-C26, C64, C7A, C7B, D10-D36, D3A]
Phase IV    [1]
Soft Tissue Sarcoma
[ICD9: 171   ICD10: C49]
Phase II    [1]
Structure

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InChI1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(
20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7
-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)
(H,8,9)/b17-12-;/t;2-/m.0/s1
InChIKeyLBWFXVZLPYTWQI-IPOVEDGCSA-N
Canonical SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=
O)O    
Isomeric SMILESCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=
O)O)O)C(=O)O
CAS NumberCAS 557795-19-4
FormulaC22H27FN4O2
PubChem Compound IDCID 6456015.
PubChem Substance IDSID 10560397.
ChEBI38940;
SuperDrug ATC IDL01XE04
L01XE04
ClinicalTrials.govNCT00753727;
NCT01073644;
TargetFL cytokine receptorInhibitor[2][3][4]
FL cytokine receptorMultitarget[2][3][4]
Mast/stem cell growth factor receptorInhibitor[2][3][4]
Mast/stem cell growth factor receptorMultitarget[2][3][4]
Platelet-derived growth factor receptorInhibitor[2][3][4]
Platelet-derived growth factor receptorMultitarget[2][3][4]
Vascular endothelial growth factor receptor 2Inhibitor[2][3][4]
Vascular endothelial growth factor receptor 2Multitarget[2][3][4]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Pfizer. Product Development Pipeline. March 31 2009. To Reference
Ref 3Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 2009 Feb;37(2):359-65. Epub 2008 Oct 29. To Reference
Ref 4A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference



 

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