Therapeutic Targets Database
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TTD Drug ID: DCL000695

Drug Information
NameAmibegron
SynonymsCID 3035442; LS-187094; D08850; UNII-PDQ3ME68U3; 121524-08-1; amibegron; SR 58611; ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate; AC1MHZDD; CID3035442; Amibegron (USAN/INN)
CompanySanofi-Aventis & Eli Lilly
IndicationMajor Depressive Disorders,Obesity, Diabetes Type 2
[ICD9: 250, 250.00, 250.02, 278, 296, 296.2, 296.3   ICD10: E08-E13, E11, E66, F30-F39, F32, F33]
Preclinical    [1]
Major Depressive Disorders,Severe Mood Disorders
[ICD9: 296, 296.2, 296.3   ICD10: F30-F39, F32, F33]
Discontined in Phase III    [1]
Structure

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InChI1S/C22H26ClNO4/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-2
0)24-13-21(25)16-4-3-5-18(23)10-16/h3-5,7,9-10,12,19,21,24-25H,2,
6,8,11,13-14H2,1H3/t19-,21-/m0/s1
InChIKeyRDJQCOBTKKAQAH-FPOVZHCZSA-N
Canonical SMILESCCOC(=O)COC1=CC2=C(CCC(C2)NCC(C3=CC(=CC=C3)Cl)O)C=C1    
Isomeric SMILESCCOC(=O)COC1=CC2=C(CC[C@@H](C2)NC[C@@H](C3=CC(=CC=C3)Cl)O)C=C1
CAS NumberCAS 121524-08-1
FormulaC22H26ClNO4
PubChem Compound IDCID 3035442.
PubChem Substance IDSID 14830696.
ClinicalTrials.govNCT00855530;
TargetBeta-3 adrenergic receptorAgonist[1]
Ref 1Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. To Reference



 

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