Therapeutic Targets Database
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TTD Drug ID: DCL000698

Drug Information
NameAplindore fumarate
Synonyms189681-71-8; Aplindore fumarate; Aplindore fumarate (USAN); D03214; AC1O5U60; (2S)-2-[(benzylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-8-one; (E)-but-2-enedioic acid; 8H-1,4-Dioxino(2,3-e)indol-8-one,2,3,7,9-tetrahydro-2-(((phenylmethyl)amino)methyl)-,2(S)-, (2E)-2-butenediotate (1:1); LS-193407; WAY-DAB-452; CID6440763; Aplindore; UNII-P13TV5A758
CompanyWyeth
IndicationSchizophrenia
[ICD9: 295   ICD10: F20]
Phase II    [1]
Structure

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InChI1S/C18H18N2O3.C4H4O4/c21-17-8-14-15(20-17)6-7-16-18(14)23-13(11-2
2-16)10-19-9-12-4-2-1-3-5-12;5-3(6)1-2-4(7)8/h1-7,13,19H,8-11H2,(
H,20,21);1-2H,(H,5,6)(H,7,8)/b;2-1+/t13-;/m0./s1
InChIKeyGELJVTSEGKGLDF-QDSMGTAFSA-N
Canonical SMILESC1C(OC2=C(O1)C=CC3=C2CC(=O)N3)CNCC4=CC=CC=C4.C(=CC(=O)O)C(=O)O    
Isomeric SMILESC1[C@@H](OC2=C(O1)C=CC3=C2CC(=O)N3)CNCC4=CC=CC=C4.C(=C/C(=O)O)\C(=O)O
CAS NumberCAS 189681-71-8
FormulaC22H22N2O7
PubChem Compound IDCID 6440763.
PubChem Substance IDSID 736227.
TargetD(2) dopamine receptorAgonist[1][2]
Ref 1The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. To Reference
Ref 2Eur J Pharmacol. 2006 Dec 15;552(1-3):36-45. Epub 2006 Sep 14.Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist. To Reference



 

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