Therapeutic Targets Database
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TTD Drug ID: DCL000704

Drug Information
NameAsimadoline
SynonymsBenzeneacetamide, N-(2-(3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)-N-methyl-alpha-phenyl-, (S-(R*,R*))-; AC1L452B; EMD 61753; Benzeneacetamide, N-((1S)-2-((3S)-3-hydroxy-1-pyrrolidinyl)-1-phenylethyl)-N-methyl-alpha-phenyl-; 153205-46-0; UNII-D0VK52NV5M; CID179340; Asimadoline [INN]; Asimadoline; N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide
CompanyMerck
IndicationDiarrhea Predominant Irritable Bowel Syndrome
[ICD9: 564.1   ICD10: K58.0]
Phase III    [1]
Structure

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InChI1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)
27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-
20H2,1H3/t24-,25+/m0/s1
InChIKeyJHLHNYVMZCADTC-LOSJGSFVSA-N
Canonical SMILESCN(C(CN1CCC(C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4    
Isomeric SMILESCN([C@H](CN1CC[C@@H](C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
CAS NumberCAS 153205-46-0
PubChem Compound IDCID 179340.
PubChem Substance IDSID 756584.
SuperDrug ATC IDR05DA11
SuperDrug CAS ID036309010;
ClinicalTrials.govNCT01100684;
TargetKappa-type opioid receptorAgonist[1]
Ref 1Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. To Reference



 

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