Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000752

Drug Information
SynonymsCilomilast; DB03849; 1xom; 153259-65-5; PDSP2_001271; CHEMBL511115; S1455_Selleck; Cilomilast (JAN/USAN/INN); D01704; Cilomilast [USAN:INN]; Ariflo; LS-56637; AC1L45SU; cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic acid; SB207499; CIO; CID151170; Ariflo (TN); C433247; Ariflo, SB-207499,Cilomilast; cis-4-Cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid; NCGC00167520-01; 1xlx; CHEBI:221895; cis-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-4-cyanocyclohexane-1-carboxylic acid; SB 207499; CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID; PDSP1_001287; Cyclohexanecarboxylic acid, 4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, cis-; 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1- carboxylic acid; MolPort-005-940-870; MolPort-005-943-371; SB-207499; 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
IndicationAsthma, Chronic obstructive pulmonary disease (COPD)
[ICD9: 460-519, 490-492, 493, 494-496   ICD10: J00-J99, J40-J44, J45, J47]
Suspended in Phase II in GSK 2005 Report    [1]
Emphysema, Bronchitis, Chronic obstructive pulmonary disease
[ICD9: 460-519, 466, 490, 490-492, 491, 492, 494-496   ICD10: J00-J99, J20-J21, J40-J44, J42, J43, J47]
Suspended in Phase III in GSK 2005 Report    [1]

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Canonical SMILESCOC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3    
CAS NumberCAS 153259-65-5
PubChem Compound IDCID 151170.
PubChem Substance IDSID 585708.
TargetCAMP-specific 3',5'-cyclic phosphodiesterase 4AInhibitor[1]
Phosphodiesterase 4Inhibitor[2]
Ref 1Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. To Reference
Ref 2Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. To Reference


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