Therapeutic Targets Database
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TTD Drug ID: DCL000778

Drug Information
NameDoripenem
SynonymsCHEMBL491571; Doripenem; FT-0081127; CID73303; NCGC00167510-01; S 4661; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-(((aminosulfonyl)amino)methyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(3S*,5S*),4alpha,5beta,6beta(R*)))-; 148016-81-3; S-4661; (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; I14-8431; Doribax; D03895; AC1L2JMJ; UNII-BHV525JOBH; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((aminosulfonyl)amino)methyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)-; Doripenem (USAN/INN)
CompanyShionogi /penisula
IndicationGram-positive excluding Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus and -negative including P. aeruginosa
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
Phase III    [1]
Structure

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InChI1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26
-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,
23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChIKeyAVAACINZEOAHHE-VFZPANTDSA-N
Canonical SMILESCC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O    
Isomeric SMILESC[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)CNS(=O)(=O)N)C(=O)O)
[C@@H](C)O
CAS NumberCAS 148016-81-3
PubChem Compound IDCID 73303.
PubChem Substance IDSID 215547.
SuperDrug ATC IDJ01DH04
J01DH04
ClinicalTrials.govNCT00589693;
TargetBacterial outer membraneInhibitor[1]
Ref 1Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. To Reference



 

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