Therapeutic Targets Database
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TTD Drug ID: DCL000811

Drug Information
NameGanaxolone
SynonymsCID11537287; GANAXOLONE; Pregnan-20-one, 3-hydroxy-3-methyl-, (3alpha,5alpha)-; AC1OCF9O; 38398-32-2; Ganaxolone (USAN/INN); D04300; NCGC00165802-02; CID6918305; CHEBI:370090; NCGC00165802-03; CCD 1042; CID38022; UNII-98WI44OHIQ; 3alpha-Hydroxy-3-methyl-5alpha-pregnan-20-one; CHEMBL161915; G7795_SIGMA; 1-[(3R,5S,10S,13S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone; 3alpha-Hydroxy-3beta-methyl-5alpha-pregnan-20-one; LS-118581; CCD-1042; (3alpha,5alpha)-3-Hydroxy-3-methylpregnan-20-one; C22H36O2; Ganaxolone [USAN]; AC1L1YWW
CompanyMarinus
IndicationEpilepsy
[ICD9: 345   ICD10: G40]
Phase II completed    [1]
Structure

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InChI1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3
)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16+,17-,18+,1
9+,20-,21+,22-/m1/s1
InChIKeyPGTVWKLGGCQMBR-HNABIGDDSA-N
Canonical SMILESCC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)(C)O)C)C    
Isomeric SMILESCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@@](C4)(C)
O)C)C
CAS NumberCAS 38398-32-2
FormulaC22H36O2
PubChem Compound IDCID 11537287.
PubChem Substance IDSID 16639382.
ClinicalTrials.govNCT00465517;
TargetGamma-aminobutyric acid receptorModulator[2][1][3]
Ref 1Epilepsy Res. 2009 Jan;83(1):1-43. Epub 2008 Nov 12.Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). To Reference
Ref 2Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. To Reference
Ref 3New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs. 2006 Jun;15(6):637-47. To Reference



 

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