Therapeutic Targets Database
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TTD Drug ID: DCL000827

Drug Information
NameGSK-677954
CompanyGSK
IndicationNon-alcoholic fatty liver disease (NAFLD)
[ICD9: 571.8   ICD10: K76.0]
Discontinued in Phase II    [1]
Structure

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InChI1S/C34H36F3N3O4S2/c1-4-33(5-2,32(41)42)44-27-14-16-28(17-15-27)45
-22-29-30(38-31(46-29)23-6-8-24(9-7-23)34(35,36)37)40-20-18-39(19
-21-40)25-10-12-26(43-3)13-11-25/h6-17H,4-5,18-22H2,1-3H3,(H,41,4
2)
InChIKeyCOHCTXOFKQXTRQ-UHFFFAOYSA-N
Canonical SMILESCCC(CC)(C(=O)O)OC1=CC=C(C=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)N4CCN
(CC4)C5=CC=C(C=C5)OC    
CAS NumberCAS 884324-15-6
PubChem Compound IDCID 56603715.
TargetPeroxisome proliferator-activated receptor alpha (PPAR-alpha)Agonist[1]
Peroxisome proliferator-activated receptor alpha (PPAR-alpha)Multitarget[1]
Peroxisome proliferator-activated receptor delta (PPAR-delta)Agonist[1]
Peroxisome proliferator-activated receptor delta (PPAR-delta)Multitarget[1]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)Agonist[1]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)Multitarget[1]
Ref 1Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. To Reference



 

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