Therapeutic Targets Database
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TTD Drug ID: DCL000841

Drug Information
NameIdazoxan
SynonymsIdazoxano [Spanish]; 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole; Idazoxan [BAN:INN]; 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole; NCGC00024794-03; Potassium dicopper trichloride; AB00514632; Idazoxanum; Prestwick1_000926; nchembio705-12; 79944-58-4; AC1L1H1U; BPBio1_000916; ST51055467; C10968; I14-6697; Prestwick0_000926; CID54459; Prestwick2_000926; (+-)-2-(1,4-Benzodioxan-2-yl)-2-imidazoline; Idazoxane; L000808; BSPBio_000832; CHEBI:5862; LS-78447; SPBio_003011; NCGC00024794-04; NCGC00015560-08; Idazoxane [French]; Prestwick3_000926; 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole; CHEMBL10316; 1H-Imidazole, 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-; Idazoxano; IDAZOXAN; BRD-A18696154-003-03-6; Lopac0_000652; HMS2089E14; RX-781094; Idazoxanum [Latin]
CompanyYamanouchi / Astellas
IndicationMajor Depressive Disorder, Parkinsoní»s Disease
[ICD9: 296.2, 296.3, 332   ICD10: F02.3, F32, F33, G20]
Withdrawn in Phase III    [1]
Structure

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InChI1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10
H,5-7H2,(H,12,13)
InChIKeyHPMRFMKYPGXPEP-UHFFFAOYSA-N
Canonical SMILESC1CN=C(N1)C2COC3=CC=CC=C3O2    
CAS NumberCAS 79944-56-2
PubChem Compound IDCID 54459.
PubChem Substance IDSID 13151.
ChEBI5862;
ClinicalTrials.govNCT00294944;
TargetAlpha-2 adrenergic receptorAntagonist[2]
Ref 1The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. To Reference
Ref 2Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. To Reference



 

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