Therapeutic Targets Database
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TTD Drug ID: DCL000897

Drug Information
NameNetoglitazone
SynonymsNetoglitazone (USAN/INN); CID204109; Netoglitazone; Netoglitazone [USAN]; D05150; UNII-QOV2JZ647A; 5-[[6-[(2-fluorophenyl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione; RWJ-241947; CHEMBL93747; MolPort-005-942-719; MCC 555; AC1L4BXM; 5-({6-[(2-fluorobenzyl)oxy]naphthalen-2-yl}methyl)-1,3-thiazolidine-2,4-dione; C115174; Isaglitazone; 161600-01-7; 2,4-Thiazolidinedione, 5-((6-((2-fluorophenyl)methoxy)-2-naphthalenyl)methyl)-; 5-((6-((2-fluorophenyl)methoxy)-2-naphthalenyl)methyl)-2,4-thiazolidinedione; MCC-555
CompanyMitsubishi Pharma
IndicationNon-alcoholic fatty liver disease (NAFLD)
[ICD9: 571.8   ICD10: K76.0]
Phase II    [1]
Structure

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InChI1S/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(1
4)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,2
5)
InChIKeyPKWDZWYVIHVNKS-UHFFFAOYSA-N
Canonical SMILESC1=CC=C(C(=C1)COC2=CC3=C(C=C2)C=C(C=C3)CC4C(=O)NC(=O)S4)F    
CAS NumberCAS 161599-99-1
PubChem Compound IDCID 204109.
PubChem Substance IDSID 779983.
TargetPeroxisome proliferator-activated receptor alpha (PPAR-alpha)Agonist[2]
Peroxisome proliferator-activated receptor alpha (PPAR-alpha)Multitarget[2]
Peroxisome proliferator-activated receptor delta (PPAR-delta)Agonist[2]
Peroxisome proliferator-activated receptor delta (PPAR-delta)Multitarget[2]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)Agonist[2]
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)Multitarget[2]
Ref 1Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. To Reference
Ref 2Evolution of peroxisome proliferator-activated receptor agonists. Ann Pharmacother. 2007 Jun;41(6):973-83. Epub 2007 May 22. To Reference



 

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