Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000902

Drug Information
Synonyms(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; NVP-LAQ824, Dacinostat, LAQ824; CHEMBL356066; AC1O62SB; NVP-LAQ 824; NVP-LAQ824; I14-11726; Dacinostat; UNII-V10P524501; EC-000.2469; 404951-53-7; LAQ-824; LS-192513; S1095_Selleck; CID6445533; 2-Propenamide, N-hydroxy-3-(4-(((2-hydroxyethyl)(2-(1H-indol-3-yl)ethyl)amino)methyl)phenyl)-, (2E)-; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; nchembio.313-comp12
CompanyCorcept Therapeutics
IndicationGeneral leukaemia cancer
[ICD9: 204-208   ICD10: C91-C95]
Discontinued in Phase I/II    [1]
Severe Mood Disorders
[ICD9: 296   ICD10: F30-F39]
Phase III    [1]

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Canonical SMILESC1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)C=CC(=O)NO    
Isomeric SMILESC1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO
PubChem Compound IDCID 6445533.
PubChem Substance IDSID 789434.
SuperDrug ATC IDG03XB01
SuperDrug CAS ID084371653;
TargetHistone deacetylase Inhibitor[2]
Histone deacetylase Inhibitor[3]
Ref 1Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. To Reference
Ref 2Blood. 2003 Oct 1;102(7):2615-22. Epub 2003 Jun 19.NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. To Reference
Ref 3Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. To Reference


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