Therapeutic Targets Database
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TTD Drug ID: DCL000957

Drug Information
NameRevatropate
Synonyms[(3R)-1-azabicyclo[2.2.2]octan-3-yl] (2R)-2-(hydroxymethyl)-4-methylsulfinyl-2-phenylbutanoate; CID3035836; CID6918246; UK-112166; CID9690123; UNII-3W7L15V40W; AC1OCF7F; CID9554797; AC1MI026; UK-112,166; [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (2S)-2-(hydroxymethyl)-4-methylsulfinyl-2-phenylbutanoate; Revatropate; Benzenacetic acid, alpha-(hydroxymethyl)-alpha-(2-(methylsulfinyl)ethyl)-, 1-azabicyclo(2.2.2)oct-3-yl ester, (3R-(3R*(S*(R*))))-; (3R-(3R*(S*(R*))))-1-Azabicyclo(2.2.2)oct-3-yl alpha-(hydroxymethyl)-alpha-(2-(methylsulfinyl)ethyl)benzenacetate; UK-112166-04; 149926-91-0
CompanyPfizer
IndicationChronic obstructive pulmonary disease
[ICD9: 490-492, 494-496   ICD10: J40-J44, J47]
Discontinued in Phase I    [1]
Structure

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InChI1S/C19H27NO4S/c1-25(23)12-9-19(14-21,16-5-3-2-4-6-16)18(22)24-17-
13-20-10-7-15(17)8-11-20/h2-6,15,17,21H,7-14H2,1H3/t17-,19-,25-/m
0/s1
InChIKeyVGXACJMXDYPFDB-KMEZTADASA-N
Canonical SMILESCS(=O)CCC(CO)(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3    
Isomeric SMILESC[S@](=O)CC[C@](CO)(C1=CC=CC=C1)C(=O)O[C@H]2CN3CCC2CC3
CAS NumberCAS 149926-91-0
FormulaC19H27NO4S
PubChem Compound IDCID 9690123.
PubChem Substance IDSID 12014788.
TargetMuscarinic acetylcholine receptor M1Antagonist[1]
Muscarinic acetylcholine receptor M1Multitarget[1]
Muscarinic acetylcholine receptor M3Antagonist[1]
Muscarinic acetylcholine receptor M3Multitarget[1]
Ref 1Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. To Reference



 

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