Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL000959

Drug Information
NameRho-kinase inhibitor
SynonymsH-1152P; (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine, 2HCl; H-1152; Rho Kinase Inhibitor; InSolution™ Rho Kinase Inhibitor
CompanyCoTherix
IndicationPulmonary arterial hypertension
[ICD9: 416.0   ICD10: I27.0, I27.2]
Phase II    
Structure

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InChI1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)1
9-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/
t13-;;/m1../s1
InChIKeyBFOPDSJOLUQULZ-FFXKMJQXSA-N
Canonical SMILESCC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl    
Isomeric SMILESC[C@@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl
PubChem Compound IDCID 16760633.
PubChem Substance IDSID 26759444.
TargetRho kinaseInhibitor[1]
Ref 1Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. To Reference



 

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