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TTD Drug ID: DCL000970

Drug Information
NameRuboxistaurin
Synonyms169939-94-0; 1uu3; LS-187626; LY-333531; LS-186984; CID153999; CHEMBL91829; 9H,18H-5,21:12,17-Dimethenodibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecine-18,20(19H)-dione, 9-((dimethylamino)methyl)-6,7,10,11-tetrahydro-, (9S)-; Ruboxistaurin; LY-333,531; (9S)-9-((Dimethylamino)methyl)-6,7,10,11-tetrahydro-9H,19H-5,21:12,17-dimethenodibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-18,20-dione; AC1L4BIF; K00587a; LY333531; 13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione; LY 333531; Ruboxistaurin [INN]; LY4; UNII-721809WQCP
CompanyEli Lilly, USA
IndicationDiabetic Macular Edema
[ICD9: 362.07   ICD10: E08.3, E09.3, E10.3, E11.3, E13.3]
Discontinued    [1]
Structure

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InChI1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25
-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h
3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1
InChIKeyZCBUQCWBWNUWSU-SFHVURJKSA-N
Canonical SMILESCN(C)CC1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O    
Isomeric SMILESCN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=
O
CAS NumberCAS 202260-21-7
PubChem Compound IDCID 153999.
PubChem Substance IDSID 731401.
ClinicalTrials.govNCT00133952;
TargetProtein kinase C beta type (PKC-beta)Inhibitor[1]
Ref 1Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63. To Reference



 

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