Therapeutic Targets Database
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TTD Drug ID: DCL000995

Drug Information
NameSNS-595
Synonymsvosaroxin; CID 9952884; AG 7352; SPC-595; CHEMBL68117; SNS 595; CID9952884; 175414-77-4; Voreloxin (USAN); D08024; Voreloxin; SNS-595; 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid; AG-7352; SPC 595; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-methoxy-4-(methylamino)-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-, (3S-trans)-; ( )-AG-7352
Trade NameVoreloxin; SNS 595; SNS-595; SPC 595; AG 7352
CompanySunesis Pharmaceuticals, Inc.
IndicationOvarian cancer
[ICD9: 183   ICD10: C56]
Phase II    [1]
Structure

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InChI1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(2
5)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,
(H,25,26)/t12-,13-/m0/s1
InChIKeyXZAFZXJXZHRNAQ-STQMWFEESA-N
Canonical SMILESCNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O    
Isomeric SMILESCN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O
CAS NumberCAS 175414-77-4
FormulaC18H19N5O4S
PubChem Compound IDCID 9952884.
PubChem Substance IDSID 14928277.
ClinicalTrials.govNCT00408603;
TargetDNA topoisomerase 2Inhibitor[1]
Ref 1Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36. To Reference



 

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