Therapeutic Targets Database
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TTD Drug ID: DCL001010

Drug Information
NameTA-2005
SynonymsCID63951; CHF-4226; 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]-1H-quinolin-2-one hydrochloride; 8-Hydroxy-5-(1-hydroxy-2-(N-(2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril hydrochloride; AC1L204L; AC1Q3ER2; 100429-08-1; 8-Hydroxy-5-((1R)-1-hydroxy-2-(N-(1R)-2-(p-methoxyphenyl)isopropylamino)ethyl)carbostyril HCl; 8-hydroxy-5-[(1r)-1-hydroxy-2-{[(2r)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]quinolin-2(1h)-one hydrochloride(1:1); Carmoterol hydrochloride; 2(1H)-Quinolinone, 8-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)-, hydrochloride, (R-(R*,R*))-; LS-142795; 2(1H)-Quinolinone, 8-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)-, monohydrochloride, (R-(R*,R*))-; CHF 4226.01; 137888-11-0; TA-2005
CompanyChiesi
IndicationChronic obstructive pulmonary disease
[ICD9: 490-492, 494-496   ICD10: J40-J44, J47]
Phase II completed    [1]
Structure

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InChI1S/C21H24N2O4.ClH/c1-13(11-14-3-5-15(27-2)6-4-14)22-12-19(25)16-7
-9-18(24)21-17(16)8-10-20(26)23-21;/h3-10,13,19,22,24-25H,11-12H2
,1-2H3,(H,23,26);1H/t13-,19+;/m1./s1
InChIKeySYCWERNQGSKYAG-QVRIGTRMSA-N
Canonical SMILESCC(CC1=CC=C(C=C1)OC)NCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O.Cl    
Isomeric SMILESC[C@H](CC1=CC=C(C=C1)OC)NC[C@@H](C2=C3C=CC(=O)NC3=C(C=C2)O)O.Cl
FormulaC21H25ClN2O4
PubChem Compound IDCID 63951.
PubChem Substance IDSID 206017.
ClinicalTrials.govNCT00640484;
TargetBeta-2 adrenergic receptorAgonist[1]
Ref 1Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. To Reference



 

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