Therapeutic Targets Database
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TTD Drug ID: DCL001022

Drug Information
NameTraxoprodil
SynonymsTraxoprodil; 1-Piperidineethanol, 4-hydroxy-alpha-(4-hydroxyphenyl)-beta-methyl-4-phenyl-, (alphaS,betaS)-; CID219101; 15571-11-6; ( )-CP 101606; LS-184042; 1-Piperidineethanol, 4-hydroxy-alpha-(4-hydroxyphenyl)-beta-methyl-4-phenyl-, (S-(R*,R*))-; AC1L5621; CP101606; CP-101606; AC1Q59EY; CHEMBL17350; CP 98113; CHEBI:119774; Traxoprodil [INN]; CP 101,606; AR-1B8535; CP 101606; 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol; KST-1B0691
CompanyPfizer
IndicationParkinson's DiseaseDiscontinued in Phase I    [1]
Severe Mood Disorders
[ICD9: 296   ICD10: F30-F39]
Discontinued in Phase II    [1]
Structure

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InChI1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-1
4-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s
1
InChIKeyQEMSVZNTSXPFJA-HNAYVOBHSA-N
Canonical SMILESCC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O    
Isomeric SMILESC[C@@H]([C@H](C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O
Therapeutic ClassAnalgesics
CAS NumberCAS 189894-57-3
FormulaC20H25NO3
PubChem Compound IDCID 219101.
PubChem Substance IDSID 791640.
ClinicalTrials.govNCT00163059;
TargetNMDA receptorsubunit epsilon-2 Antagonist[2]
NMDA receptorsubunit epsilon-2 Antagonist[1][2]
Ref 1Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. To Reference
Ref 2Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. To Reference



 

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