Therapeutic Targets Database
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TTD Drug ID: DCL001035

Drug Information
NameVestipitant
CompanyGlaxoSmithKline
IndicationAnxiety disorder, chemotherapyinduced emesis, dyspepsia, major depressive disorder
[ICD9: 296.2, 296.3, 300, 536.8, 787   ICD10: F32, F33, F40-F42, K30, R11]
Discontinued in Phase II    [1]
Structure

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InChI1S/C23H24F7N3O/c1-13-8-18(24)4-5-19(13)20-12-31-6-7-33(20)21(34)3
2(3)14(2)15-9-16(22(25,26)27)11-17(10-15)23(28,29)30/h4-5,8-11,14
,20,31H,6-7,12H2,1-3H3/t14-,20-/m1/s1
InChIKeySBBYBXSFWOLDDG-JLTOFOAXSA-N
Canonical SMILESCC1=C(C=CC(=C1)F)C2CNCCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F    
Isomeric SMILESCC1=C(C=CC(=C1)F)[C@H]2CNCCN2C(=O)N(C)[C@H](C)C3=CC(=CC(=C3)C(F)(F)F)C
(F)(F)F
CAS NumberCAS 334476-46-9
FormulaC23H24F7N3O
PubChem Compound IDCID 9832383.
TargetNK-1 antagonist (neurokinin)Antagonist[2]
Ref 1Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. To Reference
Ref 2Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. To Reference



 

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