Therapeutic Targets Database
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TTD Drug ID: DCL001068

Drug Information
NameAT-9283
SynonymsCID 11496629; AT-9283; pyrazole-benzimidazole urea analogue, 16; CHEMBL495727; CID11496629
CompanyAstex
IndicationAdult solid tumours, NHL, AML, ALL, CML, MDS and myelofibrosis
[ICD9: 140-199, 200, 202, 204.0, 205.0, 205.1, 210-229, 289.83, 758.33   ICD10: C00-C75, C7A, C7B, C82-C85, C91.0, C92.0, C92.1, C94.4, D10-D36, D3A, D47.1, Q93.88]
Phase I/II    
Structure

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InChI1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4
-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13,20,25H,2-3,5
-8,11H2,(H2,21,24,27)/b18-17+
InChIKeyVRXXZJLHPWWXIX-ISLYRVAYSA-N
Canonical SMILESC1CC1NC(=O)NC2=CNNC2=C3N=C4C=CC(=CC4=N3)CN5CCOCC5    
Isomeric SMILESC1CC1NC(=O)NC\2=CNN/C2=C/3\N=C4C=CC(=CC4=N3)CN5CCOCC5
FormulaC17H13N5O
PubChem Compound IDCID 11496629.
PubChem Substance IDSID 42575492.
ClinicalTrials.govNCT00522990;
TargetAurora AInhibitor[1]
Aurora AMultitarget[1]
Aurora BInhibitor[1]
Aurora BMultitarget[1]
Ref 1Nat Rev Drug Discov. 2009 Jul;8(7):547-66.Cell cycle kinases as therapeutic targets for cancer. To Reference



 

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