Therapeutic Targets Database
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TTD Drug ID: DCL001070

Drug Information
NameCYC-116
SynonymsCHEBI:620120; CHEMBL482967; CID6420138; CYC-116, CYC116; Kinome_636; S1171_Selleck; AC1O4WKE; CYC-116; 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine; 2c5t
CompanyCyclacel
IndicationAdvanced solid tumours
[ICD9: 140-199   ICD10: C00-C75, C7A, C7B]
Terminated in Phase I    
Structure

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InChI1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-
4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,2
2,23)
InChIKeyGPSZYOIFQZPWEJ-UHFFFAOYSA-N
Canonical SMILESCC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4    
PubChem Compound IDCID 6420138.
PubChem Substance IDSID 11618518.
ClinicalTrials.govNCT00530465;
TargetAurora AInhibitor[1]
Aurora AMultitarget[1]
Aurora BInhibitor[1]
Aurora BMultitarget[1]
Ref 1Nat Rev Drug Discov. 2009 Jul;8(7):547-66.Cell cycle kinases as therapeutic targets for cancer. To Reference



 

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