Therapeutic Targets Database
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TTD Drug ID: DCL001085

Drug Information
NameBEZ235
SynonymsBEZ235; NVP-BEZ235, BEZ235; CID11977753; EC-000.2325; BEZ-235; 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile; Kinome_2911; ZINC24760115; S14-0511; CID 11977753; NVP-BEZ-235; S1009_Selleck; nchembio.117-comp24; ST51056474; MolPort-005-737-784
CompanyNovartis
IndicationAdvanced solid tumours; Advanced breast cancer
[ICD9: 140-199, 140-229, 174, 175, 210-229   ICD10: C00-C75, C00-C96, C50, C7A, C7B, D10-D36, D3A]
Phase I/II    
Structure

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InChI1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-
14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36
/h4-17H,1-3H3
InChIKeyJOGKUKXHTYWRGZ-UHFFFAOYSA-N
Canonical SMILESCC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=
C5    
PubChem Compound IDCID 11977753.
PubChem Substance IDSID 17429886.
ClinicalTrials.govNCT01195376;
TargetPI3KInhibitor[1]
PI3KMultitarget[1]
Serine/threonine-protein kinase mTORInhibitor[1]
Serine/threonine-protein kinase mTORMultitarget[1]
Ref 1Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. To Reference



 

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