Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DCL001168

Drug Information
NameCabozantinib
CompanyExelixis
IndicationBreast Cancer, Gastric/GE Junctional Cancer, Hepatocellular Carcinoma, Melanoma, Castration-Resistant Prostate Cancer, Non-small Cell Lung Cancer, Ovarian Cancer, Pancreatic Cancer, Small Cell Lung Cance
[ICD9: 140-229, 155, 157, 162, 172, 174, 175, 183, 185, 204.0   ICD10: C00-C96, C22.0, C25, C33, C33-C34, C34, C43, C50, C56, C61, C91.0]
Phase II    [1]
Differentiated Thyroid Cancer, Renal Cell Carcinoma
[ICD9: 140-229, 189, 193   ICD10: C00-C96, C64, C73]
Phase Ib    [1]
Medullary Thyroid Cancer
[ICD9: 193   ICD10: C73]
Phase III    [1]
Metastatic Castration-Resistant Prostate Cancer, Ovarian Cancer
[ICD9: 140-229, 183, 185   ICD10: C00-C96, C56, C61]
Phase II    [1]
Structure

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InChI1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-
20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-
18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChIKeyONIQOQHATWINJY-UHFFFAOYSA-N
Canonical SMILESCOC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F    
CAS NumberCAS 849217-68-1
PubChem Compound IDCID 25102847.
TargetMet proto-oncogene tyrosine kinaseInhibitor[1]
Met proto-oncogene tyrosine kinaseMultitarget[1]
Vascular endothelial growth factor receptor 2Inhibitor[1]
Vascular endothelial growth factor receptor 2Multitarget[1]
Ref 12011 Pipeline of Exelixis. To Reference



 

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