Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC000017

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESCOC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3    
Isomeric SMILESCOC1=C(C=C(C=C1)[C@@H]2CC(=O)NC2)OC3CCCC3
CAS NumberCAS 216974-75-3
PubChem Compound IDCID 158758.
PubChem Substance IDSID 736201.
TargetCAMP-specific 3',5'-cyclic phosphodiesterase 4AInhibitor[1]
CAMP-specific 3',5'-cyclic phosphodiesterase 4BInhibitor[1]
Phosphodiesterase isozyme 4Inhibitor[1][2]
Ref 1PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. Epub 2009 Mar 20. To Reference
Ref 2Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. Anticancer Drugs. 2003 Jun;14(5):377-81. To Reference


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