Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC000130

Drug Information
NameABT-418
IndicationNot AvailableExperimental    
Structure

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InChI1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-
/m0/s1
InChIKeyILLGYRJAYAAAEW-QMMMGPOBSA-N
Canonical SMILESCC1=NOC(=C1)C2CCCN2C    
Isomeric SMILESCC1=NOC(=C1)[C@@H]2CCCN2C
CAS NumberCAS 147402-53-7
PubChem Compound IDCID 119380.
PubChem Substance IDSID 696060.
TargetNeuronal acetylcholine receptor protein, alpha-4 chainAgonist[1]
Neuronal acetylcholine receptor protein, beta-2 chainAgonist[2][1]
Nicotinic acetylcholine receptorAgonist[3]
Ref 1(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28. To Reference
Ref 2Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44. To Reference
Ref 3Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl). 1999 May;144(2):175-82. To Reference



 

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