Therapeutic Targets Database
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TTD Drug ID: DNC000402

Drug Information
NameCEP-751
IndicationNot AvailableExperimental    
Structure

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InChI1S/C27H23N3O4/c1-26-27(13-31,33-2)11-19(34-26)29-17-9-5-3-7-14(17
)21-22-16(12-28-25(22)32)20-15-8-4-6-10-18(15)30(26)24(20)23(21)2
9/h3-10,19,31H,11-13H2,1-2H3,(H,28,32)/t19?,26-,27-/m0/s1
InChIKeyNMMGUHANGUWNBN-OGLOGDKOSA-N
Canonical SMILESCC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)OC    
Isomeric SMILESC[C@@]12[C@](CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)
(CO)OC
PubChem Compound IDCID 9868524.
TargetProto-oncogene tyrosine-protein kinase receptor retInhibitor[1]
Ref 1CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res. 2003 Sep 1;63(17):5559-63. To Reference



 

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