Therapeutic Targets Database
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TTD Drug ID: DNC000443

Drug Information
NameCL-316,243
IndicationNot AvailableExperimental    
Structure

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InChI1S/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6
-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H
,7,10H2,1H3,(H,24,25)(H,26,27);;/t11-,15+;;/m1../s1
InChIKeyUVJBVPHQFYWKJL-CFOQQKEYSA-N
Canonical SMILESCC(CC1=CC2=C(C=C1)OC(O2)(C(=O)O)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O.[Na].[Na]    
Isomeric SMILESC[C@H](CC1=CC2=C(C=C1)OC(O2)(C(=O)O)C(=O)O)NC[C@@H](C3=CC(=CC=C3)Cl)O.
[Na].[Na]
CAS NumberCAS 138908-40-4
FormulaC20H20ClNNa2O7
PubChem Compound IDCID 6335907.
PubChem Substance IDSID 696052.
TargetBeta-3 adrenergic receptorAgonist[1]
Mitochondrial brown fat uncoupling protein 1Inducer[2]
Mitochondrial uncoupling protein 2Inducer[2]
Mitochondrial uncoupling protein 3Inducer[2]
Ref 1Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans. Curr Pharm Des. 2001 Sep;7(14):1433-49. To Reference
Ref 2Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. To Reference



 

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