Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC000449

Drug Information
NameClobenpropit
IndicationNot AvailableExperimental    
Structure

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InChI1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-1
0-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
InChIKeyUCAIEVHKDLMIFL-UHFFFAOYSA-N
Canonical SMILESC1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl    
CAS NumberCAS 145231-45-4
PubChem Compound IDCID 2790.
PubChem Substance IDSID 685320.
TargetHistamine H3 receptorAntagonist[1][2]
Histamine H4 receptorAgonist[3][4]
Ref 1The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. To Reference
Ref 2Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9. To Reference
Ref 3Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. Bioorg Med Chem. 2009 Jun 1;17(11):3987-94. Epub 2009 Apr 11. To Reference
Ref 4The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol. 2009 Mar;123(3):619-25. To Reference



 

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