Therapeutic Targets Database
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TTD Drug ID: DNC000525

Drug Information
NameDDATHF
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-
5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-1
0H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12?,15-/m0/s1
InChIKeyZUQBAQVRAURMCL-CVRLYYSRSA-N
Canonical SMILESC1C(CNC2=C1C(=O)N=C(N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O    
Isomeric SMILESC1C(CNC2=C1C(=O)N=C(N2)N)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
CAS NumberCAS 95693-76-8
PubChem Compound IDCID 105040.
PubChem Substance IDSID 682516.
TargetGlycinamide ribonucleotide formyltransferaseInhibitor[1]
Ref 1Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99. To Reference



 

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