Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC000700

Drug Information
NameGo6976
IndicationNot AvailableExperimental    
Structure

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InChI1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15
-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2
,1H3,(H,26,29)
InChIKeyVWVYILCFSYNJHF-UHFFFAOYSA-N
Canonical SMILESCN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O    
CAS NumberCAS 56-17-7
PubChem Compound IDCID 3501.
PubChem Substance IDSID 618246.
TargetNuclear factor NF-kappa-BInhibitor[1]
Protein kinase CInhibitor[2]
Protein kinase C, zeta typeInhibitor[3]
Ref 1Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8542-7. To Reference
Ref 2The protein kinase C inhibitor G?6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 2003 Jan 1;63(1):31-5. To Reference
Ref 3Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. To Reference



 

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