Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC001280

Drug Information
NameSB 203580
IndicationNot AvailableExperimental    
Structure

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InChI1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-
3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChIKeyCDMGBJANTYXAIV-UHFFFAOYSA-N
Canonical SMILESCS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F    
CAS NumberCAS 152121-47-6
PubChem Compound IDCID 176155.
PubChem Substance IDSID 753357.
TargetInterleukin 1 receptorAntagonist[1]
Mitogen-activated protein kinase 14Inhibitor[2][3]
Prostaglandin G/H synthase 2Inhibitor[4]
Ref 1IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J Cell Physiol. 2001 Jun;187(3):294-303. To Reference
Ref 2The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment. Blood. 2001 Aug 1;98(3):667-73. To Reference
Ref 3Mini Rev Med Chem. 2007 Nov;7(11):1108-19.Privileged structures: a useful concept for the rational design of new lead drug candidates. To Reference
Ref 4Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000 May;47(2-3):185-201. To Reference



 

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