Therapeutic Targets Database
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TTD Drug ID: DNC001325

Drug Information
NameSIB-1508Y
IndicationNot AvailableExperimental    
Structure

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InChI1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-
6H2,2H3
InChIKeyNUPUDYKEEJNZRG-UHFFFAOYSA-N
Canonical SMILESCN1CCCC1C2=CN=CC(=C2)C#C    
CAS NumberCAS 192231-16-6
PubChem Compound IDCID 133106.
PubChem Substance IDSID 15586747.
TargetNeuronal acetylcholine receptor protein, beta-2 chainAgonist[1]
Nicotinic acetylcholine receptorAgonist[2][3]
Ref 1Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44. To Reference
Ref 2Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression. Psychopharmacology (Berl). 2000 Oct;152(3):295-303. To Reference
Ref 3Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J Pharmacol Exp Ther. 1999 Aug;290(2):731-9. To Reference



 

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