Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Drug ID: DNC001435

Drug Information
NameThioperamide
IndicationObesity
[ICD9: 278   ICD10: E66]
Experimental    
Structure

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InChI1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-
11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
InChIKeyQKDDJDBFONZGBW-UHFFFAOYSA-N
Canonical SMILESC1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3    
CAS NumberCAS 106243-16-7
PubChem Compound IDCID 3035905.
PubChem Substance IDSID 705782.
TargetHistamine H3 receptorAntagonist[1][2]
Histamine H4 receptorAntagonist[3][4][1]
Ref 1The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. To Reference
Ref 2Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9. To Reference
Ref 3Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86. Epub 2008 Sep 11. To Reference
Ref 4Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. Neuroimmunomodulation. 2007;14(6):317-25. Epub 2008 Apr 10. To Reference



 

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