Therapeutic Targets Database
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TTD Drug ID: DNC003505

Drug Information
NameGR-127935
SynonymsGR-127935
IndicationNot AvailableExperimental    
Structure

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InChI1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-2
2(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-3
4/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)
InChIKeyYDBCEBYHYKAFRX-UHFFFAOYSA-N
Canonical SMILESCC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN
(CC5)C    
TargetSerotonin 1a (5-HT1a) receptorInhibitor[1]
Serotonin 1b (5-HT1b) receptorInhibitor[2]
Serotonin 1d (5-HT1d) receptorInhibitor[2]
Serotonin 2a (5-HT2a) receptorInhibitor[2]
Serotonin 2c (5-HT2c) receptorInhibitor[2]
Ref 1J Med Chem. 2000 Feb 10;43(3):517-25.New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides. To Reference
Ref 2Bioorg Med Chem Lett. 2005 Nov 1;15(21):4786-9.Synthesis of potent and selective serotonin 5-HT1B receptor ligands. To Reference



 

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