Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC003523

Drug Information
IndicationNot AvailableExperimental    

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Canonical SMILESC1=CC=C2C(=C1)C=CC(=O)C2=O    
Acyl coenzyme A:cholesterol acyltransferaseInhibitor[1]
Indoleamine 2,3-dioxygenaseInhibitor[2]
Protein-tyrosine phosphatase 1BInhibitor[3]
Ref 1J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. To Reference
Ref 2J Med Chem. 2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. To Reference
Ref 3Bioorg Med Chem Lett. 2002 Aug 5;12(15):1941-6.Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents. To Reference


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